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Articles / 6 minute read

What Is Methylation?

And Why Is It Important for Your Health and Longevity?

Have you heard the buzz about methylation? It's a crucial process happening inside your body right now, billions of times every second! Understanding methylation can help you unlock better health, more energy, and longer life.

What Exactly Is Methylation?

Methylation is a natural chemical process in every cell of your body. It involves adding a tiny molecule called a methyl gron atom and three up (one carbohydrogen atoms) to other molecules. This small change has a big impact by regulating how your cells function.

Methylation supports many vital functions, including:123

  • Producing creatine for muscle strength
  • Regulating hormones and detoxifying your body
  • Generating energy at the cellular level
  • Repairing cell membranes
  • Breaking down fats efficiently
  • Protecting nerve fibers with myelin
  • Supporting your immune system
  • Creating neurotransmitters that balance mood
  • Maintaining healthy blood vessels and circulation
  • Controlling DNA and gene expression for overall health

When methylation is working well, your body thrives. When it's off, health problems can arise.

Signs Your Methylation Might Be Off

Poor methylation is linked to many common and serious health issues, such as:2345

  • Chronic fatigue and low energy
  • High blood pressure and heart disease
  • Obesity and type 2 diabetes
  • Certain cancers
  • Neurodegenerative diseases like Parkinson's and Alzheimer's
  • Mental health challenges including anxiety, depression, and bipolar disorder

If you experience any of these, methylation could be a factor, and testing can help reveal the root cause.

One substance turns into another with the help of special proteins called enzymes (shown in blue boxes). These enzymes need certain nutrients like B vitamins and minerals to work properly. Without enough of these nutrients, the enzymes can't do their job well.4

How Can You Tell if Your Methylation Is Working Properly?

Your body runs a complex methylation cycle powered by enzymes that depend on essential nutrients like B vitamins and minerals. Genetic variations can slow down or speed up these enzymes, affecting methylation balance.6

You can measure methylation health by:

  • Testing for genetic markers (Methylation Genomics test)
  • Checking levels of key byproducts like homocysteine (linked to heart disease) and SAMe (your body's main methyl donor).

This information helps personalize your health plan.

How to Optimize Your Methylation for Better Health

Great news! You can support healthy methylation naturally! Here's how:

  • Eat enough protein: Your body needs amino acids from eggs, fish, meat, nuts, and seeds to fuel methylation.7
  • Get plenty of B vitamins: Vitamins B2, B3, B6, B12, and folate are essential. Leafy greens, dairy, and meats are good sources, or consider supplements with active forms like methylcobalamin.8
  • Ensure mineral intake: Magnesium and zinc help enzymes work better. Find these in whole grains, nuts, leafy vegetables, and red meat.9
  • Limit alcohol and smoking: These deplete important nutrients and harm methylation.101112
  • Avoid toxins: Exposure to heavy metals and chemicals can disrupt DNA methylation.10 Learn more about these toxins using the A-Z Index at the Agency for Toxic Substances and Disease Registry (ATSDR).
  • Manage stress: Stress increases the demand on methylation and nutrient use.11
  • Stay active: Regular exercise helps maintain healthy weight and supports methylation balance.11

Testing can guide targeted supplementation and lifestyle changes tailored just for you, if needed.

Methylation and Healthy Aging

Because methylation supports so many critical functions, optimizing it can help slow aging and reduce risk of chronic disease. It's never too early or too late to support your methylation pathway for improved energy, mental clarity, and longevity.

Take control of your health by learning about your methylation status today. Testing and personalized support can unlock your body's full potential for wellness and longevity!

Methylation Genomics

Discover Your Cellular Buleprint

HSA/FSA Eligible CLIA-Certified Lab

You can take the same test featured in this article from the comfort of your home.

Use the Methylation Genomics test to pinpoint the hormonal root-cause of your insomnia with an at-home saliva test and finally wake up refreshed.


This article is for educational purposes and not medical advice. Always consult a qualified healthcare provider.